@article {6927,
	title = {Non-redundant coding of aversive odours in the main olfactory pathway.},
	journal = {Nature},
	volume = {497},
	year = {2013},
	month = {2013 May 23},
	pages = {486-9},
	abstract = {<p>Many species are critically dependent on olfaction for survival. In the main olfactory system of mammals, odours are detected by sensory neurons that express a large repertoire of canonical odorant receptors and a much smaller repertoire of trace amine-associated receptors (TAARs). Odours are encoded in a combinatorial fashion across glomeruli in the main olfactory bulb, with each glomerulus corresponding to a specific receptor. The degree to which individual receptor genes contribute to odour perception is unclear. Here we show that genetic deletion of the olfactory Taar gene family, or even a single Taar gene (Taar4), eliminates the aversion that mice display to low concentrations of volatile amines and to the odour of predator urine. Our findings identify a role for the TAARs in olfaction, namely, in the high-sensitivity detection of innately aversive odours. In addition, our data reveal that aversive amines are represented in a non-redundant fashion, and that individual main olfactory receptor genes can contribute substantially to odour perception.</p>
},
	keywords = {Amines, Animals, Avoidance Learning, Female, G-Protein-Coupled, Male, Mice, Models, Neurological, Odorant, Odors, Olfactory Bulb, Olfactory Pathways, Olfactory Receptor Neurons, Predatory Behavior, Receptors, Smell, Urine},
	issn = {1476-4687},
	doi = {10.1038/nature12114},
	author = {Dewan, Adam and Pacifico, Rodrigo and Zhan, Ross and Rinberg, Dmitry and Bozza, Thomas}
}
