@article {6135,
	title = {High-throughput behavioral analysis in C. elegans.},
	journal = {Nature Methods},
	volume = {8},
	year = {2011},
	month = {2011 Jun 5},
	pages = {592-8},
	abstract = {<p>We designed a real-time computer vision system, the Multi-Worm Tracker (MWT), which can simultaneously quantify the behavior of dozens of Caenorhabditis elegans on a Petri plate at video rates. We examined three traditional behavioral paradigms using this system: spontaneous movement on food, where the behavior changes over tens of minutes; chemotaxis, where turning events must be detected accurately to determine strategy; and habituation of response to tap, where the response is stochastic and changes over time. In each case, manual analysis or automated single-worm tracking would be tedious and time-consuming, but the MWT system allowed rapid quantification of behavior with minimal human effort. Thus, this system will enable large-scale forward and reverse genetic screens for complex behaviors.</p>
},
	keywords = {Animal, Animals, Behavior, Caenorhabditis elegans, Chemotaxis, Computer-Assisted, Image Processing, Movement, Software, Stochastic Processes, Time Factors},
	issn = {1548-7105},
	doi = {10.1038/nmeth.1625},
	author = {Swierczek, Nicholas A and Giles, Andrew C and Rankin, Catharine H and Kerr, Rex A}
}
