@article {1238,
	title = {Optimal information storage in noisy synapses under resource constraints.},
	journal = {Neuron},
	volume = {52},
	year = {2006},
	month = {2006 Nov 9},
	pages = {409-23},
	abstract = {<p>Experimental investigations have revealed that synapses possess interesting and, in some cases, unexpected properties. We propose a theoretical framework that accounts for three of these properties: typical central synapses are noisy, the distribution of synaptic weights among central synapses is wide, and synaptic connectivity between neurons is sparse. We also comment on the possibility that synaptic weights may vary in discrete steps. Our approach is based on maximizing information storage capacity of neural tissue under resource constraints. Based on previous experimental and theoretical work, we use volume as a limited resource and utilize the empirical relationship between volume and synaptic weight. Solutions of our constrained optimization problems are not only consistent with existing experimental measurements but also make nontrivial predictions.</p>
},
	keywords = {Animals, Excitatory Postsynaptic Potentials, Information Storage and Retrieval, Memory, Models, Neurological, Synapses, Synaptic Transmission},
	issn = {0896-6273},
	doi = {10.1371/journal.pcbi.1001066},
	author = {Varshney, Lav R and Sj{\"o}str{\"o}m, Per Jesper and Chklovskii, Dmitri B}
}
