@article {1690,
	title = {Life sciences require the third dimension.},
	journal = {Current Opinion in Cell Biology},
	volume = {18},
	year = {2006},
	month = {2006 Feb},
	pages = {117-24},
	abstract = {<p>Novel technologies are required for three-dimensional cell biology and biophysics. By three-dimensional we refer to experimental conditions that essentially try to avoid hard and flat surfaces and favour unconstrained sample dynamics. We believe that light-sheet-based microscopes are particularly well suited to studies of sensitive three-dimensional biological systems. The application of such instruments can be illustrated with examples from the biophysics of microtubule dynamics and three-dimensional cell cultures. Our experience leads us to suggest that three-dimensional approaches reveal new aspects of a system and enable experiments to be performed in a more physiological and hence clinically more relevant context.</p>
},
	keywords = {Animals, Biological Science Disciplines, Cell Line, Computer-Assisted, Dogs, Fluorescence, Image Processing, Imaging, Microscopy, Microtubules, Paclitaxel, Three-Dimensional},
	issn = {0955-0674},
	doi = {10.1016/j.ceb.2005.12.012},
	author = {Keller, Philipp J and Pampaloni, Francesco and Stelzer, Ernst H K}
}
