@article {2320,
	title = {L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons.},
	journal = {Brain Research. Molecular Brain Research},
	volume = {131},
	year = {2004},
	month = {2004 Nov 24},
	pages = {65-72},
	abstract = {<p>Dopamine (DA) receptor-mediated signal transduction and gene expression play a central role in many brain disorders from schizophrenia to Parkinson{\textquoteright}s disease to addiction. While trying to evaluate the role of L-type Ca2+ channels in dopamine D1 receptor-mediated phosphorylation of the transcription factor cyclic AMP response element-binding protein (CREB), we found that activation of dopamine D1 receptors alters the properties of L-type Ca2+ channel inhibitors and turns them into facilitators of Ca2+ influx. In D1 receptor-stimulated neurons, L-type Ca2+ channel blockers promote cytosolic Ca2+ accumulation. This leads to the activation of a molecular signal transduction pathway and CREB phosphorylation. In the absence of dopamine receptor stimulation, L-type Ca2+ channel blockers inhibit CREB phosphorylation. The effect of dopamine on L-type Ca2+ channel blockers is dependent on protein kinase A (PKA), suggesting that protein phosphorylation plays a role in this phenomenon. Because of the adverse effect of activated dopamine receptors on L-type Ca2+ channel blocker action, the role of L-type Ca2+ channels in the dopamine D1 receptor signal transduction pathway cannot be assessed with pharmacological tools. However, with antisense technology, we demonstrate that L-type Ca2+ channels contribute to D1 receptor-mediated CREB phosphorylation. We conclude that the D1 receptor signal transduction pathway depends on L-type Ca2+ channels to mediate CREB phosphorylation.</p>
},
	keywords = {2, 3, 4, 5-Tetrahydro-7, 8-dihydroxy-1-phenyl-1H-3-benzazepine, Animals, Antisense, Calcium, Calcium Channel Blockers, Calcium Channels, Cells, Corpus Striatum, Cultured, Cyclic AMP Response Element-Binding Protein, Dizocilpine Maleate, Dopamine Antagonists, Dopamine D1, Drug Interactions, Excitatory Amino Acid Antagonists, Female, L-Type, N-Methyl-D-Aspartate, Neurons, Nifedipine, Oligonucleotides, Phosphorylation, Pregnancy, Rats, Receptors, Sprague-Dawley},
	issn = {0169-328X},
	doi = {10.3389/fnana.2010.00147},
	author = {Eaton, Molly E and Mac{\'\i}as, Wendy and Youngs, Rachael M and Rajadhyaksha, Anjali and Dudman, Joshua T and Konradi, Christine}
}
