@article {1139,
	title = {X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males.},
	journal = {PLoS Biology},
	volume = {2},
	year = {2004},
	month = {2004 Nov},
	pages = {e341},
	abstract = {<p>It has been proposed that dosage compensation in Drosophila males occurs by binding of two core proteins, MSL-1 and MSL-2, to a set of 35-40 X chromosome "entry sites" that serve to nucleate mature complexes, termed compensasomes, which then spread to neighboring sequences to double expression of most X-linked genes. Here we show that any piece of the X chromosome with which compensasomes are associated in wild-type displays a normal pattern of compensasome binding when inserted into an autosome, independently of the presence of an entry site. Furthermore, in chromosomal rearrangements in which a piece of X chromosome is inserted into an autosome, or a piece of autosome is translocated to the X chromosome, we do not observe spreading of compensasomes to regions of autosomes that have been juxtaposed to X chromosomal material. Taken together these results suggest that spreading is not involved in dosage compensation and that nothing distinguishes an entry site from the other X chromosome sites occupied by compensasomes beyond their relative affinities for compensasomes. We propose a new model in which the distribution of compensasomes along the X chromosome is achieved according to the hierarchical affinities of individual binding sites.</p>
},
	keywords = {Animals, Binding Sites, Chromosomes, Crosses, DNA-Binding Proteins, Dosage Compensation, Drosophila, Drosophila Proteins, Female, Fluorescence, Genetic, Genotype, In Situ Hybridization, Male, Microscopy, Nuclear Proteins, Protein Binding, Sex Factors, Transcription Factors, Translocation, X Chromosome},
	issn = {1545-7885},
	doi = {10.1371/journal.pbio.0020341},
	author = {Fagegaltier, Delphine and Baker, Bruce S}
}
