@article {2135,
	title = {LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites.},
	journal = {Nature Neuroscience},
	volume = {7},
	year = {2004},
	month = {2004 Feb},
	pages = {126-35},
	abstract = {<p>The propagation and integration of signals in the dendrites of pyramidal neurons is regulated, in part, by the distribution and biophysical properties of voltage-gated ion channels. It is thus possible that any modification of these channels in a specific part of the dendritic tree might locally alter these signaling processes. Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the activation of NMDA receptors. These changes favored the back-propagation of action potentials into this dendritic region with a subsequent boost in the Ca(2+) influx. Dendritic cell-attached patch recordings revealed a hyperpolarized shift in the inactivation curve of transient, A-type K(+) currents that can account for the enhanced excitability. These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function.</p>
},
	keywords = {Action Potentials, Animals, Calcium, Dendrites, Excitatory Postsynaptic Potentials, Hippocampus, Ion Channels, Long-Term Potentiation, Memory, N-Methyl-D-Aspartate, Neuronal Plasticity, Organ Culture Techniques, Patch-Clamp Techniques, Rats, Receptors},
	issn = {1097-6256},
	doi = {10.1002/cbic.201000254},
	author = {Frick, Andreas and Magee, Jeffrey and Johnston, Daniel}
}
