@article {2458,
	title = {Disruption of a behavioral sequence by targeted death of peptidergic neurons in Drosophila.},
	journal = {Neuron},
	volume = {19},
	year = {1997},
	month = {1997 Oct},
	pages = {813-23},
	abstract = {<p>The neuropeptide eclosion hormone (EH) is a key regulator of insect ecdysis. We tested the role of the two EH-producing neurons in Drosophila by using an EH cell-specific enhancer to activate cell death genes reaper and head involution defective to ablate the EH cells. In the EH cell knockout flies, larval and adult ecdyses were disrupted, yet a third of the knockouts emerged as adults, demonstrating that EH has a significant but nonessential role in ecdysis. The EH cell knockouts had discrete behavioral deficits, including slow, uncoordinated eclosion and an insensitivity to ecdysis-triggering hormone. The knockouts lacked the lights-on eclosion response despite having a normal circadian eclosion rhythm. This study represents a novel approach to the dissection of neuropeptide regulation of a complex behavioral program.</p>
},
	keywords = {Animals, Cell Death, Circadian Rhythm, Crosses, Darkness, DNA Transposable Elements, Drosophila, Embryo, Genetic, Green Fluorescent Proteins, Insect Hormones, Invertebrate, Larva, Light, Luminescent Proteins, Mutagenesis, Neurons, Neuropeptides, Nonmammalian, Photoreceptor Cells, Recombinant Fusion Proteins},
	issn = {0896-6273},
	author = {McNabb, S L and Baker, J D and Agapite, J and Steller, H and Riddiford, L M and Truman, J W}
}
