@article {971,
	title = {Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.},
	journal = {Science},
	volume = {250},
	year = {1990},
	month = {1990 Dec 7},
	pages = {1370-7},
	abstract = {<p>In the development of multicellular organisms a diversity of cell types differentiate at specific positions. Spacing patterns, in which an array of two or more cell types forms from a uniform field of cells, are a common feature of development. Identical precursor cells may adopt different fates because of competition and inhibition between them. Such a pattern in the developing Drosophila eye is the evenly spaced array of R8 cells, around which other cell types are subsequently recruited. Genetic studies suggest that the scabrous mutation disrupts a signal produced by R8 cells that inhibits other cells from also becoming R8 cells. The scabrous locus was cloned, and it appears to encode a secreted protein partly related to the beta and gamma chains of fibrinogen. It is proposed that the sca locus encodes a lateral inhibitor of R8 differentiation. The roles of the Drosophila EGF-receptor homologue (DER) and Notch genes in this process were also investigated.</p>
},
	keywords = {Alleles, Amino Acid Sequence, Animals, Cell Differentiation, DNA Transposable Elements, Drosophila, Drosophila Proteins, Epidermal Growth Factor, Eye, Fibrinogen, Glycoproteins, Humans, Molecular Sequence Data, Mosaicism, Mutation, Nucleic Acid, Phenotype, Proteins, Receptor, Sequence Homology},
	issn = {0036-8075},
	doi = {10.1186/gb-2007-8-7-r145},
	author = {Baker, N E and Mlodzik, M and Rubin, G M}
}
