@article {1175,
	title = {Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate.},
	journal = {Cell},
	volume = {56},
	year = {1989},
	month = {1989 Jan 13},
	pages = {131-9},
	abstract = {<p>Using complementary oligonucleotide probes, we have isolated the nuclear gene for the RNA moiety of RNAase MRP; it is present as a single copy and encodes an uncapped primary transcript of 275 nucleotides. Direct sequence analysis revealed that the 136 nucleotide RNA that copurifies with RNAase MRP represents the 3{\textquoteright} half of the 275 nucleotide primary transcript. The 5{\textquoteright}-flanking region of the gene has putative transcriptional control elements homologous to the promoters of RNA polymerase II-transcribed U-series snRNA genes; however, the coding region possesses a box A sequence and terminates at four T residues, both features characteristic of polymerase III-transcribed genes. A decamer sequence, 5{\textquoteright}-CGA-CCCCUCC-3{\textquoteright}, complementary to a conserved sequence adjacent to the enzymatic cleavage site on the mitochondrial RNA substrate, is present in the RNAase MRP RNA. Isolation of a nuclear gene for the RNA component of a mitochondrial enzyme implies that nucleic acids can be transported across mitochondrial membranes.</p>
},
	keywords = {Animals, Blotting, DNA, Endoribonucleases, Genes, Genetic, Mice, Mitochondria, Mitochondrial, Nucleic Acid, Oligonucleotide Probes, Post-Transcriptional, Ribonucleases, RNA Processing, Sequence Homology, Southern, Transcription},
	issn = {0092-8674},
	doi = {10.1101/gad.1352105},
	author = {Chang, D D and Clayton, D A}
}
