@article {45165,
	title = {A spike-timing mechanism for action selection.},
	journal = {Nature Neuroscience},
	volume = {17},
	year = {2014},
	month = {2014 Jul 17},
	pages = {962-70},
	abstract = {<p>We discovered a bimodal behavior in the genetically tractable organism Drosophila melanogaster that allowed us to directly probe the neural mechanisms of an action selection process. When confronted by a predator-mimicking looming stimulus, a fly responds with either a long-duration escape behavior sequence that initiates stable flight or a distinct, short-duration sequence that sacrifices flight stability for speed. Intracellular recording of the descending giant fiber (GF) interneuron during head-fixed escape revealed that GF spike timing relative to parallel circuits for escape actions determined which of the two behavioral responses was elicited. The process was well described by a simple model in which the GF circuit has a higher activation threshold than the parallel circuits, but can override ongoing behavior to force a short takeoff. Our findings suggest a neural mechanism for action selection in which relative activation timing of parallel circuits creates the appropriate motor output.</p>
},
	issn = {1546-1726},
	doi = {10.1038/nn.3741},
	author = {von Reyn, Catherine R and Breads, Patrick and Peek, Martin Y and Zheng, Grace Zhiyu and Williamson, W Ryan and Yee, Alyson L and Leonardo, Anthony and Card, Gwyneth M}
}
