@article {45917,
	title = {Dendritic spikes induce single-burst long-term potentiation.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {104},
	year = {2007},
	month = {2007 Oct 23},
	pages = {17192-7},
	abstract = {<p>The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong activation by a single burst. The induction mechanism of this single-burst LTP requires activation of NMDA receptors, L-type voltage-gated calcium channels, and dendritic spikes. Thus, dendritic spikes are a critical trigger for a form of LTP that is consistent with the function of the hippocampus in episodic memory.</p>
},
	keywords = {Action Potentials, Animals, Dendrites, Excitatory Postsynaptic Potentials, Inhibitory Postsynaptic Potentials, Long-Term Potentiation, Pyramidal Cells, Rats, Rats, Wistar, Synapses},
	issn = {0027-8424},
	doi = {10.1073/pnas.0707919104},
	author = {Remy, Stefan and Spruston, Nelson}
}
