@article {46702,
	title = {The translation elongation factor eEF1A1 couples transcription to translation during heat shock response.},
	journal = {eLife},
	volume = {3},
	year = {2014},
	month = {2014 Sep 16},
	pages = {e03164},
	abstract = {<p>Translation elongation factor eEF1A has a well-defined role in protein synthesis. In this study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat shock response (HSR) in mammalian cells from transcription through translation. Upon stress, isoform 1 of eEF1A rapidly activates transcription of HSP70 by recruiting the master regulator HSF1 to its promoter. eEF1A1 then associates with elongating RNA polymerase II and the 3{\textquoteright}UTR of HSP70 mRNA, stabilizing it and facilitating its transport from the nucleus to active ribosomes. eEF1A1-depleted cells exhibit severely impaired HSR and compromised thermotolerance. In contrast, tissue-specific isoform 2 of eEF1A does not support HSR. By adjusting transcriptional yield to translational needs, eEF1A1 renders HSR rapid, robust, and highly selective; thus, representing an attractive therapeutic target for numerous conditions associated with disrupted protein homeostasis, ranging from neurodegeneration to cancer.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.03164},
	author = {Vera, Maria and Pani, Bibhusita and Griffiths, Lowri A and Muchardt, Christian and Abbott, Catherine M and Singer, Robert H and Nudler, Evgeny}
}
