@article {46887,
	title = {Synaptic Orb2A bridges memory acquisition and late memory consolidation in Drosophila.},
	journal = {Cell Reports},
	volume = {11},
	year = {2015},
	month = {2015 Jun 30},
	pages = {1953-65},
	abstract = {<p>To adapt to an ever-changing environment, animals consolidate some, but not all, learning experiences to long-term memory. In mammals, long-term memory consolidation often involves neural pathway reactivation hours after memory acquisition. It is not known whether this delayed-reactivation schema is\&nbsp;common across the animal kingdom or how information is stored during the delay period. Here, we show\&nbsp;that, during courtship suppression learning, Drosophila exhibits delayed long-term memory consolidation. We also show that the same class of dopaminergic neurons engaged earlier in memory acquisition is also both necessary and sufficient for delayed long-term memory consolidation. Furthermore, we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII. Thus, our results provide evidence for the role of a neuromodulated, synapse-restricted molecule bridging memory acquisition and long-term memory consolidation in a learning animal.</p>
},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2015.05.037},
	author = {Kr{\"u}ttner, Sebastian and Traunm{\"u}ller, Lisa and Dag, Ugur and Jandrasits, Katharina and Stepien, Barbara and Iyer, Nirmala and Fradkin, Lee G and Noordermeer, Jasprina N and Mensh, Brett D and Keleman, Krystyna}
}
