@article {47300,
	title = {Axonal filtering allows reliable output during dendritic plateau-driven complex spiking in CA1 neurons.},
	journal = {Neuron},
	volume = {89},
	year = {2016},
	month = {2016 Feb 17},
	pages = {770-783},
	abstract = {<p>In CA1 pyramidal neurons, correlated inputs trigger dendritic plateau potentials that drive neuronal plasticity and firing rate modulation. Given the strong electrotonic coupling between soma and axon, the \&gt;25\&nbsp;mV depolarization associated with the plateau could propagate through the axon to influence action potential initiation, propagation, and neurotransmitter release. We examined this issue in brain slices, awake mice, and a computational model. Despite profoundly inactivating somatic and proximal axon Na(+) channels, plateaus evoked action potentials that recovered to full amplitude in the distal axon (\&gt;150\&nbsp;μm) and triggered neurotransmitter release similar to regular spiking. This effect was due to strong attenuation of plateau depolarizations by axonal K(+) channels, allowing full axon repolarization and Na(+) channel deinactivation. High-pass filtering of dendritic plateaus by axonal K(+) channels should thus enable accurate transmission of gain-modulated firing rates, allowing neuronal firing to be efficiently read out by downstream regions as a simple rate code.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2015.12.040},
	author = {Apostolides, Pierre F and Milstein, Aaron D and Grienberger, Christine and Bittner, Katie C and Magee, Jeffrey C}
}
