@article {47991,
	title = {The serotonergic system tracks the outcomes of actions to mediate short-term motor learning.},
	journal = {Cell},
	volume = {167},
	year = {2016},
	month = {2016 Oct 27},
	pages = {933-46},
	abstract = {<p>To execute accurate movements, animals must continuously adapt their behavior to changes in their\&nbsp;bodies and environments. Animals can learn changes in the relationship between their locomotor commands and the resulting distance moved, then adjust command strength to achieve a desired travel distance. It is largely unknown which circuits implement this form of motor learning, or how. Using whole-brain neuronal imaging and circuit manipulations in larval zebrafish, we discovered that the serotonergic dorsal raphe nucleus (DRN) mediates short-term locomotor learning. Serotonergic DRN neurons respond phasically to swim-induced visual motion, but little to motion that is not self-generated. During prolonged exposure to a given motosensory gain, persistent DRN activity emerges that stores the learned efficacy of motor commands and adapts future locomotor drive for tens of seconds. The DRN{\textquoteright}s ability to track the effectiveness of motor intent may constitute a computational building block\&nbsp;for the broader functions of the serotonergic system.</p>
},
	doi = {10.1016/j.cell.2016.09.055},
	author = {Kawashima, Takashi and Zwart, Maarten F and Yang, Chao-Tsung and Mensh, Brett D and Ahrens, Misha B}
}
