@article {48009,
	title = {A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs.},
	journal = {Nature Methods},
	volume = {14},
	year = {2017},
	month = {2017 Jan 31},
	pages = {45-8},
	abstract = {<p>Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.</p>
},
	author = {Rivas, Elena and Clements, Jody and Eddy, Sean R.}
}
