@article {48839,
	title = {Vision and locomotion shape the interactions between neuron types in mouse visual cortex.},
	journal = {Neuron},
	volume = {98},
	year = {2018},
	month = {2018 May 2},
	pages = {602-15},
	abstract = {<p>Cortical computation arises from the interaction of multiple neuronal\&nbsp;types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such\&nbsp;interactions, we imaged these four\&nbsp;types\&nbsp;of cells in\&nbsp;mouse\&nbsp;primary\&nbsp;visual\&nbsp;cortex(V1). Our recordings in darkness were consistent with a "disinhibitory" model in which\&nbsp;locomotion\&nbsp;activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when\&nbsp;visual\&nbsp;stimuli were present:\&nbsp;locomotion\&nbsp;increased Sst cell responses to large stimuli and Vip cell responses to small stimuli. A recurrent network model successfully predicted each cell type{\textquoteright}s activity from the measured activity of other\&nbsp;types. Capturing the effects of\&nbsp;locomotion, however, required allowing it to increase feedforward synaptic weights and modulate recurrent weights. This network model summarizes interneuron\&nbsp;interactions\&nbsp;and suggests that\&nbsp;locomotion\&nbsp;may alter cortical computation by changing effective synaptic connectivity.</p>
},
	doi = {https://doi.org/10.1101/058396},
	author = {Dipoppa, Mario and Ranson, Adam and Krumin, Michael and Pachitariu, Marius and Carandini, Matteo and Harris, Kenneth D}
}
