@article {64824,
	title = {Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons.},
	journal = {Nature Reviews. Neuroscience},
	volume = {20},
	year = {2019},
	month = {2019 Feb 18},
	pages = {193-204},
	abstract = {<p>The mechanistic operation of brain regions is often interpreted by partitioning constituent neurons into {\textquoteright}cell types{\textquoteright}. Historically, such cell types were broadly defined by their correspondence to gross features of the nervous system (such as cytoarchitecture). Modern-day neuroscientific techniques, enabling a more nuanced examination of neuronal properties, have illustrated a wealth of heterogeneity within these classical cell types. Here, we review the extent of this within-cell-type heterogeneity in one of the simplest cortical regions of the mammalian brain, the rodent hippocampus. We focus on the mounting evidence\&nbsp;that the classical CA3, CA1 and subiculum pyramidal cell types all exhibit prominent\&nbsp;and spatially patterned within-cell-type heterogeneity, and suggest these cell\&nbsp;types\&nbsp;provide a model system for exploring the organization and function of such heterogeneity. Given that the hippocampus is structurally simple and evolutionarily ancient,\&nbsp;within-cell-type heterogeneity is likely to be a general and crucial feature of the\&nbsp;mammalian brain.</p>
},
	issn = {1471-0048},
	doi = {10.1038/s41583-019-0125-5},
	author = {Cembrowski, Mark S and Spruston, Nelson}
}
