@article {65239,
	title = {TwoLumps ascending neurons mediate touch-evoked reversal of walking direction in Drosophila.},
	journal = {Current Biology},
	volume = {29},
	year = {2019},
	month = {2019 Nov 22},
	pages = {4337-44},
	abstract = {<p>External cues, including touch, enable walking animals to flexibly maneuver around obstacles and extricate themselves from dead-ends (for reviews, see [1-3]). In a screen for neurons that enable Drosophila melanogaster to retreat when it encounters a dead-end, we identified a pair of ascending neurons, the TwoLumps Ascending (TLA) neurons. Silencing TLA activity impairs backward locomotion, whereas optogenetic activation triggers backward walking. TLA-induced reversal is mediated in part by the Moonwalker Descending Neurons (MDNs) [4], which receive excitatory input from the TLAs. Silencing the TLAs decreases the extent to which freely walking flies back up upon encountering a physical barrier in the dark, and TLAs show calcium responses to optogenetic activation of neurons expressing the mechanosensory channel NOMPC. We infer that TLAs convey feedforward mechanosensory stimuli to transiently activate MDNs in response to anterior body touch.</p>
},
	issn = {1879-0445},
	doi = {10.1016/j.cub.2019.11.004},
	author = {Sen, Rajyashree and Wang, Kaiyu and Dickson, Barry J}
}
