@article {65752,
	title = {High precision coding in visual cortex},
	journal = {BioRxiv},
	year = {2019},
	month = {06/2019},
	pages = {679324},
	abstract = {<p>Single neurons in visual cortex provide unreliable measurements of visual features due to their high trial-to-trial variability. It is not known if this {\textquotedblleft}noise{\textquotedblright} extends its effects over large neural populations to impair the global encoding of sensory stimuli. We recorded simultaneously from \~{}20,000 neurons in mouse visual cortex and found that the neural population had discrimination thresholds of 0.3{\textdegree} in an orientation decoding task. These thresholds are \~{}100 times smaller than those reported behaviorally in mice. The discrepancy between neural and behavioral discrimination could not be explained by the types of stimuli we used, by behavioral states or by the sequential nature of trial-by-trial perceptual learning tasks. These results imply that the limits of sensory perception in mice are not set by neural noise in sensory cortex, but by the limitations of downstream decoders.</p>
},
	doi = {https://doi.org/10.1101/679324},
	author = {Stringer, Carsen and Michaelos, Michalis and Pachitariu, Marius}
}
