@article {65792,
	title = {The Statistical Structure of the Hippocampal Code for Space as a Function of Time, Context, and Value.},
	journal = {Cell},
	volume = {183},
	year = {2020},
	month = {2020 Oct 29},
	pages = {620-35},
	abstract = {<p>Hippocampal activity represents many behaviorally important variables, including context, an animal{\textquoteright}s location within a given environmental context, time, and reward. Using longitudinal calcium imaging in mice, multiple large virtual environments, and differing reward contingencies, we derived a unified probabilistic model of CA1 representations centered on a single feature-the field propensity. Each cell{\textquoteright}s propensity governs how many place fields it has per unit space, predicts its reward-related activity, and is preserved across distinct environments and over months. Propensity is broadly distributed-with many low, and some very high, propensity cells-and thus strongly shapes hippocampal representations. This results in a range of spatial codes, from sparse to dense. Propensity varied \~{}10-fold between adjacent cells in salt-and-pepper fashion, indicating substantial functional differences within a presumed cell type. Intracellular recordings linked propensity to cell excitability. The stability of each cell{\textquoteright}s propensity across conditions suggests this fundamental property has anatomical, transcriptional, and/or developmental origins.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2020.09.024},
	author = {Lee, Jae Sung and Briguglio, John J and Cohen, Jeremy D and Romani, Sandro and Lee, Albert K}
}
