@article {66024,
	title = {RNA transport and local translation in neurodevelopmental and neurodegenerative disease.},
	journal = {Nature Neuroscience},
	volume = {24},
	year = {2021},
	month = {2021 May 01},
	pages = {622-32},
	abstract = {<p>Neurons decentralize protein synthesis from the cell body to support the active metabolism of remote dendritic and axonal compartments. The neuronal RNA transport apparatus, composed of cis-acting RNA regulatory elements, neuronal transport granule proteins, and motor adaptor complexes, drives the long-distance RNA trafficking required for local protein synthesis. Over the past decade, advances in human genetics, subcellular biochemistry, and high-resolution imaging have implicated each member of the apparatus in several neurodegenerative diseases, establishing failed RNA transport and associated processes as a unifying pathomechanism. In this review, we deconstruct the RNA transport apparatus, exploring each constituent{\textquoteright}s role in RNA localization and illuminating their unique contributions to neurodegeneration.</p>
},
	issn = {1546-1726},
	doi = {10.1038/s41593-020-00785-2},
	author = {Fernandopulle, Michael S and Lippincott-Schwartz, Jennifer and Ward, Michael E}
}
