@article {67765,
	title = {Genetically identified amygdala-striatal circuits for valence-specific behaviors.},
	journal = {Nature Neuroscience},
	volume = {24},
	year = {2021},
	month = {2021 Oct 18},
	pages = {1586-1600},
	abstract = {<p>The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with either positive or negative valence, but how it processes motivationally opposing information and participates in establishing valence-specific behaviors remains unclear. Here, by targeting Fezf2-expressing neurons in the BLA, we identify and characterize two functionally distinct classes in behaving mice, the negative-valence neurons and positive-valence neurons, which innately represent aversive and rewarding stimuli, respectively, and through learning acquire predictive responses that are essential for punishment avoidance or reward seeking. Notably, these two classes of neurons receive inputs from separate sets of sensory and limbic areas, and convey punishment and reward information through projections to the nucleus accumbens and olfactory tubercle, respectively, to drive negative and positive reinforcement. Thus, valence-specific BLA neurons are wired with distinctive input-output structures, forming a circuit framework that supports the roles of the BLA in encoding, learning and executing valence-specific motivated behaviors.</p>
},
	issn = {1546-1726},
	doi = {10.1038/s41593-021-00927-0},
	author = {Zhang, Xian and Guan, Wuqiang and Yang, Tao and Furlan, Alessandro and Xiao, Xiong and Yu, Kai and An, Xu and Galbavy, William and Ramakrishnan, Charu and Deisseroth, Karl and Ritola, Kimberly and Hantman, Adam and He, Miao and Josh Huang, Z and Li, Bo}
}
