@article {67827,
	title = {Enhanced Photoinduced Electron Transfer Through a Tyrosine Relay in a De Novo Designed Protein Scaffold Bearing a Photoredox Unit and a Fe               <sup>II</sup>               S <sub>4</sub>               Site},
	journal = {ChemPhotoChem},
	volume = {5},
	year = {2021},
	month = {03/2021},
	pages = {665 - 668},
	abstract = {<p>Electron transfer (ET) processes in biology over long distances often proceed via a series of hops, which reduces the distance dependence of the rate of ET. The protein matrix itself can be involved in mediating ET directly through the participation of redox-active amino acids. We have designed an electron transfer chain incorporated into a de novo protein scaffold, which is capable of photoinduced intramolecular electron transfer between a photoredox unit and a FeIIS4\&nbsp;site through a tyrosine amino acid relay. The kinetics were characterized by nanosecond laser pulse photolysis and revealed that electron transfer from [RuIIIbpymal]3+\&nbsp;proceeds most efficiently via a tyrosine located \~{}16 {\r A} from Rubpymal (bpymal=1-((1-([2,2'-bipyridin]-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrrole-2,5-dione). Removal of the tyrosine as the electron relay station results in a 20-fold decrease in the apparent rate constant for the electron transfer.</p>
},
	issn = {2367-0932},
	doi = {10.1002/cptc.v5.710.1002/cptc.202100014},
	url = {https://onlinelibrary.wiley.com/toc/23670932/5/7},
	author = {Tebo, Alison and Quaranta, Annamaria and Pecoraro, Vincent L. and Aukauloo, Ally}
}
