@article {68113,
	title = {One engram two readouts: stimulus dynamics switch a learned behavior in Drosophila},
	journal = {bioRxiv},
	year = {2022},
	month = {2022 May 26},
	abstract = {<p>Memory guides the choices an animal makes across widely varying conditions in dynamic environments. Consequently, the most adaptive choice depends on the options available. How can a single memory support optimal behavior across different sets of choice options? We address this using olfactory learning in Drosophila. Even when we restrict an odor-punishment association to a single set of synapses using optogenetics, we find that flies still show choice behavior that depends on the options it encounters. Here we show that how the odor choices are presented to the animal influences memory recall itself. Presenting two similar odors in sequence enabled flies to not only discriminate them behaviorally but also at the level of neural activity. However, when the same odors were encountered as solitary stimuli, no such differences were detectable. These results show that memory recall is not simply a comparison to a static learned template, but can be adaptively modulated by stimulus dynamics.</p>
},
	doi = {10.1101/2022.05.24.492551},
	url = {https://doi.org/10.1101/2022.05.24.492551},
	author = {Mehrab N Modi and Adithya Rajagopalan and Herv{\'e} Rouault and Yoshinori Aso and Glenn C Turner}
}
