@article {68502,
	title = {Channel-independent function of UNC-9/Innexin in spatial arrangement of GABAergic synapses in .},
	journal = {eLife},
	volume = {11},
	year = {2022},
	month = {2022 Nov 15},
	abstract = {<p>Precise synaptic connection of neurons with their targets is essential for the proper functioning of the nervous system. A plethora of signaling pathways act in concert to mediate the precise spatial arrangement of synaptic connections. Here we show a novel role for a gap junction protein in controlling tiled synaptic arrangement in the GABAergic motor neurons in , in which their axons and synapses overlap minimally with their neighboring neurons within the same class. We found that while EGL-20/Wnt controls axonal tiling, their presynaptic tiling is mediated by a gap junction protein UNC-9/Innexin, that is localized at the presynaptic tiling border between neighboring dorsal D-type GABAergic motor neurons. Strikingly, the gap junction channel activity of UNC-9 is dispensable for its function in controlling tiled presynaptic patterning. While gap junctions are crucial for the proper functioning of the nervous system as channels, our finding uncovered the novel channel-independent role of UNC-9 in synapse patterning.</p>
},
	keywords = {Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Connexins, Membrane Proteins, Motor Neurons, Synapses},
	issn = {2050-084X},
	doi = {10.7554/eLife.80555},
	author = {Hendi, Ardalan and Niu, Long-Gang and Snow, Andrew William and Ikegami, Richard and Wang, Zhao-Wen and Mizumoto, Kota}
}
