@article {68516,
	title = {Hippocampal representations of foraging trajectories depend upon spatial context.},
	journal = {Nature Neuroscience},
	volume = {25},
	year = {2022},
	month = {2022 Dec 02},
	pages = {1693-1705},
	abstract = {<p>Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and evaluation of trajectories for learning. Do hippocampal representations differentially contribute to experience-dependent learning of trajectories across spatial and relational contexts? In this study, we trained mice to navigate to a hidden target in a physical arena or manipulate a joystick to a virtual target to collect delayed rewards. In a navigational context, calcium imaging in freely moving mice revealed that synchronous CA1 reactivation was retrospective and important for evaluation of prior navigational trajectories. In a non-navigational context, reactivation was prospective and important for initiation of joystick trajectories, even in the same animals trained in both contexts. Adaptation of trajectories to a new target was well-explained by a common learning algorithm in which hippocampal activity makes dissociable contributions to reinforcement learning computations depending upon spatial context.</p>
},
	keywords = {Animals, Hippocampus, Mental Recall, Mice, Prospective Studies, Retrospective Studies, Spatial Navigation},
	issn = {1546-1726},
	doi = {10.1038/s41593-022-01201-7},
	author = {Jiang, Wan-Chen and Xu, Shengjin and Dudman, Joshua T}
}
