@article {68829,
	title = {Not everything, not everywhere, not all at once: a study of brain-wide encoding of movement},
	journal = {bioRxiv},
	year = {2023},
	month = {2023 Jun 09},
	abstract = {<p>Activity related to movement is found throughout sensory and motor regions of the brain. However, it remains unclear how movement-related activity is distributed across the brain and whether systematic differences exist between brain areas. Here, we analyzed movement related activity in brain-wide recordings containing more than 50,000 neurons in mice performing a decision-making task. Using multiple techniques, from markers to deep neural networks, we find that movement-related signals were pervasive across the brain, but systematically differed across areas. Movement-related activity was stronger in areas closer to the motor or sensory periphery. Delineating activity in terms of sensory- and motor-related components revealed finer scale structures of their encodings within brain areas. We further identified activity modulation that correlates with decision-making and uninstructed movement. Our work charts out a largescale map of movement encoding and provides a roadmap for dissecting different forms of movement and decision-making related encoding across multi-regional neural circuits.</p>
},
	doi = {10.1101/2023.06.08.544257},
	url = {https://doi.org/10.1101/2023.06.08.544257},
	author = {Ziyue Aiden Wang and Susu Chen and Yi Liu and Dave Liu and Karel Svoboda and Nuo Li and Shaul Druckmann}
}
