@article {69372,
	title = {Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake},
	journal = {bioRxiv},
	year = {2024},
	month = {12 Apr 2024},
	abstract = {<p>Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity of specific neural populations controlling appetite and metabolism1. Leptin regulates food intake by inhibiting orexigenic agouti-related protein (AGRP) neurons and activating anorexigenic pro-opiomelanocortin (POMC) neurons2. However, while AGRP neurons regulate food intake on a rapid time scale, acute activation of POMC neurons has only a minimal effect3{\textendash}5. This has raised the possibility that there is a heretofore unidentified leptin-regulated neural population that suppresses appetite on a rapid time scale. Here, we report the discovery of a novel population of leptin-target neurons expressing basonuclin 2 (Bnc2) that acutely suppress appetite by directly inhibiting AGRP neurons. Opposite to the effect of AGRP activation, BNC2 neuronal activation elicited a place preference indicative of positive valence in hungry but not fed mice. The activity of BNC2 neurons is finely tuned by leptin, sensory food cues, and nutritional status. Finally, deleting leptin receptors in BNC2 neurons caused marked hyperphagia and obesity, similar to that observed in a leptin receptor knockout in AGRP neurons. These data indicate that BNC2-expressing neurons are a key component of the neural circuit that maintains energy balance, thus filling an important gap in our understanding of the regulation of food intake and leptin action.</p>
},
	doi = {10.1101/2024.01.25.577315},
	url = {https://www.biorxiv.org/content/early/2024/04/12/2024.01.25.577315},
	author = {Han L. Tan and Luping Yin and Yuqi Tan and Jessica Ivanov and Kaja Plucinska and Anoj Ilanges and Brian R. Herb and Putianqi Wang and Christin Kosse and Paul Cohen and Dayu Lin and Jeffrey M. Friedman}
}
