@article {69707,
	title = {Pearling Drives Mitochondrial DNA Nucleoid Distribution},
	journal = {bioRxiv},
	year = {2024},
	month = {12/2024},
	abstract = {<p>The regular distribution of mitochondrial DNA-containing nucleoids is essential for mitochondrial function and genome inheritance; however, the underlying mechanisms remain unknown. Our data reveal that mitochondria frequently undergo spontaneous and reversible pearling - a biophysical instability in which tubules undulate into regularly spaced beads. We discovered that pearling imposes a characteristic length scale, simultaneously mediating nucleoid disaggregation and establishing inter-nucleoid distancing with near-maximally achievable precision. Cristae invaginations play a dual role: lamellar cristae density determines pearling frequency and duration, and preserves the resulting nucleoid spacing after recovery. The distribution of mitochondrial genomes is thus fundamentally governed by the interplay between spontaneous pearling and cristae ultrastructure.</p>
},
	doi = {10.1101/2024.12.21.629917},
	url = {https://www.biorxiv.org/content/early/2024/12/22/2024.12.21.629917},
	author = {Landoni, Juan C. and Lycas, Matthew D. and Macuada, Josefa and Jaccard, Romeo and Obara, Christopher J. and Moore, Andrew S. and Ben Nejma, Sheda and Hoffman, David and Lippincott-Schwartz, Jennifer and Marshall, Wallace and Sturm, Gabriel and Manley, Suliana}
}
