@article {69732,
	title = {A critical initialization for biological neural networks},
	journal = {Nature},
	year = {2026},
	month = {2026 May 20},
	abstract = {<p>Intrinsically generated, brainwide neural activity displays macroscopic coordination among large populations of neurons that persists beyond the biophysical timescales of individual neurons1-3. It is not well understood how these macroscopic behaviours arise from microscopic, short-lived interactions between pairs of neurons. Here we show that the eigenvalue spectrum and dynamical properties of large-scale neural recordings in mice are similar to those produced by linear dynamics governed by a random symmetric matrix that is critically normalized. An exception was population activity in hippocampal area CA1, which resembled an efficient, uncorrelated neural code that may be optimized for information storage capacity. High-dimensional, global activity modes emerged in critically normalized artificial networks and persisted under sparse, clustered or spatial connectivity. These dynamics were useful for solving time-dependent tasks such as a zero-shot working memory task.</p>
},
	doi = {10.1038/s41586-026-10528-1},
	url = {https://doi.org/10.1038/s41586-026-10528-1},
	author = {Pachitariu, Marius and Zhong, Lin and Gracias, Alexa and Minisi, Amanda and Lopez, Crystall and Stringer, Carsen}
}
