@article {65107,
	title = {A neuronal pathway that commands deceleration in Drosophila larval light-avoidance.},
	journal = {Neuroscience Bulletin},
	volume = {35},
	year = {2019},
	month = {2019 Dec 1},
	abstract = {<p>When facing a sudden danger or aversive condition while engaged in on-going forward motion, animals transiently slow down and make a turn to escape. The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown. Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons (the PET pathway). Inhibiting neurons in the PET pathway led to defects in light-avoidance due to insufficient deceleration and head casting. On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses.</p>
},
	issn = {1995-8218},
	doi = {10.1007/s12264-019-00349-w},
	author = {Gong, Caixia and Ouyang, Zhenhuan and Zhao, Weiqiao and Wang, Jie and Li, Kun and Zhou, Peipei and Zhao, Ting and Zheng, Nenggan and Gong, Zhefeng}
}
