@article {47508,
	title = {Design and synthesis of a calcium-sensitive photocage.},
	journal = {Angewandte Chemie (International ed. in English)},
	year = {2016},
	month = {2016 May 24},
	abstract = {<p>Photolabile protecting groups (or "photocages") enable precise spatiotemporal control of chemical functionality and facilitate advanced biological experiments. Extant photocages exhibit a simple input-output relationship, however, where application of light elicits a photochemical reaction irrespective of the environment. Herein, we refine and extend the concept of photolabile groups, synthesizing the first Ca(2+) -sensitive photocage. This system functions as a chemical coincidence detector, releasing small molecules only in the presence of both light and elevated [Ca(2+) ]. Caging a fluorophore with this ion-sensitive moiety yields an "ion integrator" that permanently marks cells undergoing high Ca(2+) flux during an illumination-defined time period. Our general design concept demonstrates a new class of light-sensitive material for cellular imaging, sensing, and targeted molecular delivery.</p>
},
	issn = {1521-3773},
	doi = {10.1002/anie.201602941},
	author = {Heckman, Laurel M and Grimm, Jonathan B and Schreiter, Eric R and Kim, Charles and Verdecia, Mark A and Shields, Brenda C and Lavis, Luke D}
}
@inbook {6304,
	title = {The chemistry of small-molecule fluorogenic probes.},
	booktitle = {Progress in Molecular Biology and Translational Science},
	volume = {113},
	year = {2013},
	pages = {1-34},
	abstract = {<p>Chemical fluorophores find wide use in biology to detect and visualize different phenomena. A key advantage of small-molecule dyes is the ability to construct compounds where fluorescence is activated by chemical or biochemical processes. Fluorogenic molecules, in which fluorescence is activated by enzymatic activity, light, or environmental changes, enable advanced bioassays and sophisticated imaging experiments. Here, we detail the collection of fluorophores and highlight both general strategies and unique approaches that are employed to control fluorescence using chemistry.</p>
},
	issn = {1878-0814},
	doi = {10.1016/B978-0-12-386932-6.00001-6},
	author = {Grimm, Jonathan B and Heckman, Laurel M and Lavis, Luke D}
}
