@article {4589,
	title = {Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex.},
	journal = {Neuron},
	volume = {73},
	year = {2012},
	month = {2012 Jan 26},
	pages = {391-404},
	abstract = {<p>Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in\&nbsp;vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in\&nbsp;vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2011.11.034},
	author = {Jacob, Vincent and Petreanu, Leopoldo and Wright, Nick and Svoboda, Karel and Fox, Kevin}
}
@article {4298,
	title = {Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.},
	journal = {The Journal of Neuroscience},
	volume = {30},
	year = {2010},
	month = {2010 Apr 7},
	pages = {4927-32},
	abstract = {<p>The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.</p>
},
	keywords = {Animals, Cerebral Cortex, Dendritic Spines, Inbred C57BL, Learning, Male, Mice, Nerve Net, Neuronal Plasticity, Synapses, Transgenic, Vibrissae},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.6403-09.2010},
	author = {Wilbrecht, Linda and Holtmaat, Anthony and Wright, Nick and Fox, Kevin and Svoboda, Karel}
}
