@article {68710,
	title = {A neural basis of choking under pressure},
	journal = {Neuron},
	year = {2024},
	month = {2024 Sep 07},
	abstract = {<p>Incentives tend to drive improvements in performance. But when incentives get too high, we can "choke under pressure" and underperform right when it matters most. What neural processes might lead to choking under pressure? We studied rhesus monkeys performing a challenging reaching task in which they underperformed when an unusually large "jackpot" reward was at stake, and we sought a neural mechanism that might result in that underperformance. We found that increases in reward drive neural activity during movement preparation into, and then past, a zone of optimal performance. We conclude that neural signals of reward and motor preparation interact in the motor cortex (MC) in a manner that can explain why we choke under pressure.</p>
},
	doi = {10.1016/j.neuron.2024.08.012},
	url = {https://doi.org/10.1016/j.neuron.2024.08.012},
	author = {Adam L. Smoulder and Patrick J. Marino and Emily R. Oby and Sam E. Snyder and Hiroo Miyata and Nick P. Pavlovsky and William E. Bishop and Byron M. Yu and Steven M. Chase and Aaron P. Batista}
}
@article {67959,
	title = {Dimensionality reduction of calcium-imaged neuronal population activity},
	journal = {Nature Computational Science},
	year = {2023},
	month = {2023 Jan 01},
	abstract = {<p>Calcium imaging has been widely adopted for its ability to record from large neuronal populations. To summarize the time course of neural activity, dimensionality reduction methods, which have been applied extensively to population spiking activity, may be particularly useful. However, it is unclear if the dimensionality reduction methods applied to spiking activity are appropriate for calcium imaging. We thus carried out a systematic study of design choices based on standard dimensionality reduction methods. We also developed a novel method to perform deconvolution and dimensionality reduction simultaneously (termed CILDS). CILDS most accurately recovered the single-trial, low-dimensional time courses from calcium imaging that would have been recovered from spiking activity. CILDS also outperformed the other methods on calcium imaging recordings from larval zebrafish and mice. More broadly, this study represents a foundation for summarizing calcium imaging recordings of large neuronal populations using dimensionality reduction in diverse experimental settings.</p>
},
	doi = {10.1038/s43588-022-00390-2},
	url = {https://doi.org/10.1038/s43588-022-00390-2},
	author = {Tze Hui Koh and William E. Bishop and Takashi Kawashima and Brian B. Jeon and Ranjani Srinivasan and Sandra J. Kuhlman and Misha B. Ahrens and Steven M. Chase and Byron M. Yu}
}
