@article {68808,
	title = {Cell type-specific contributions to a persistent aggressive internal state in female Drosophila},
	journal = {bioRxiv},
	year = {2023},
	month = {2023 Jun 07},
	abstract = {<p>Persistent internal states are important for maintaining survival-promoting behaviors, such as aggression. In female\&nbsp;<em>Drosophila melanogaster</em>, we have previously shown that individually activating either aIPg or pC1d cell types can induce aggression. Here we investigate further the individual roles of these cholinergic, sexually dimorphic cell types, and the reciprocal connections between them, in generating a persistent aggressive internal state. We find that a brief 30-second optogenetic stimulation of aIPg neurons was sufficient to promote an aggressive internal state lasting at least 10 minutes, whereas similar stimulation of pC1d neurons did not. While we previously showed that stimulation of pC1e alone does not evoke aggression, persistent behavior could be promoted through simultaneous stimulation of pC1d and pC1e, suggesting an unexpected synergy of these cell types in establishing a persistent aggressive state. Neither aIPg nor pC1d show persistent neuronal activity themselves, implying that the persistent internal state is maintained by other mechanisms. Moreover, inactivation of pC1d did not significantly reduce aIPg-evoked persistent aggression arguing that the aggressive state did not depend on pC1d-aIPg recurrent connectivity. Our results suggest the need for alternative models to explain persistent female aggression.</p>
},
	doi = {10.1101/2023.06.07.543722},
	url = {https://doi.org/10.1101/2023.06.07.543722},
	author = {Hui Chiu and Alice A. Robie and Kristin M. Branson and Tanvi Vippa and Samantha Epstein and Gerald M. Rubin and David J. Anderson and Catherine E. Schretter}
}
