@article {68955,
	title = {A competitive disinhibitory network for robust optic flow processing in Drosophila},
	journal = {Nat Neurosci.},
	year = {2025},
	month = {2025 may 1},
	abstract = {<p>Many animals navigate using optic flow, detecting rotational image velocity differences between their eyes to adjust direction. Forward locomotion produces strong symmetric translational optic flow that can mask these differences, yet the brain efficiently extracts these binocular asymmetries for course control. In Drosophila melanogaster, monocular horizontal system neurons facilitate detection of binocular asymmetries and contribute to steering. To understand these functions, we reconstructed horizontal system cells{\textquoteright} central network using electron microscopy datasets, revealing convergent visual inputs, a recurrent inhibitory middle layer and a divergent output layer projecting to the ventral nerve cord and deeper brain regions. Two-photon imaging, GABA receptor manipulations and modeling, showed that lateral disinhibition reduces the output{\textquoteright}s translational sensitivity while enhancing its rotational selectivity. Unilateral manipulations confirmed the role of interneurons and descending outputs in steering. These findings establish competitive disinhibition as a key circuit mechanism for detecting rotational motion during translation, supporting navigation in dynamic environments.</p>

<p>Preprint:\&nbsp;https://doi.org/10.1101/2023.08.06.552150</p>
},
	doi = {10.1038/s41593-025-01948-9},
	url = {https://doi.org/10.1038/s41593-025-01948-9},
	author = {Mert Erginkaya and Tom{\'a}s Cruz and Margarida Brotas and Kathrin Steck and Aljoscha Nern and Filipa Torr{\~a}o and N{\'e}lia Varela and Davi Bock and Michael Reiser and M Eugenia Chiappe}
}
