@article {49369,
	title = {Inhibitory control of prefrontal cortex by the claustrum.},
	journal = {Neuron},
	volume = {99},
	year = {2018},
	month = {2018 Aug 07},
	pages = {1029-39},
	abstract = {<p>The claustrum is a small subcortical nucleus that has extensive excitatory connections with many cortical areas. While the anatomical connectivity from the claustrum to the cortex has been studied intensively, the physiological effect and underlying circuit mechanisms of claustrocortical communication remain elusive. Here we show that the claustrum provides strong, widespread, and long-lasting feedforward inhibition of the prefrontal cortex (PFC) sufficient to silence ongoing neural activity. This claustrocortical feedforward inhibition was predominantly mediated by interneurons containing neuropeptide Y, and to a lesser extent those containing parvalbumin. Therefore, in contrast to other long-range excitatory inputs to the PFC, the claustrocortical pathway is designed to provide overall inhibition of cortical activity. This unique circuit organization allows the claustrum to rapidly and powerfully suppress cortical networks and suggests a distinct role for the claustrum in regulating cognitive processes in prefrontal circuits.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2018.07.031},
	author = {Jackson, Jesse and Karnani, Mahesh M and Zemelman, Boris V and Burdakov, Denis and Lee, Albert K}
}
@article {6488,
	title = {Optogenetics: potentials for addiction research.},
	journal = {Addiction Biology},
	volume = {16},
	year = {2011},
	month = {2011 Oct},
	pages = {519-31},
	abstract = {<p>Research on the biology of addiction has advanced significantly over the last 50 years expanding our understanding of the brain mechanisms underlying reward, reinforcement and craving. Novel experimental approaches and techniques have provided an ever increasing armory of tools to dissect behavioral processes, neural networks and molecular mechanisms. The ultimate goal is to reintegrate this knowledge into a coherent, mechanistic framework of addiction to help identify new treatment. This can be greatly facilitated by using tools that allow, with great spatial and temporal specificity, to link molecular changes with altered activation of neural circuits and behavior. Such specificity can now be achieved by using optogenetic tools. Our review describes the general principles of optogenetics and its use to understand the links between neural activity and behavior. We also provide an overview of recent studies using optogenetic tools in addiction and consider some outstanding questions of addiction research that are particularly amenable for optogenetic approaches.</p>
},
	keywords = {Animals, Brain, Dopamine, Gene Expression, Genetic Techniques, Humans, Light, Nerve Net, Nerve Tissue Proteins, Neurons, Neurosciences, Optical Tweezers, Rhodopsin, Substance-Related Disorders, Translational Medical Research, Voltage-Sensitive Dye Imaging},
	issn = {1369-1600},
	doi = {10.1111/j.1369-1600.2011.00386.x},
	author = {Cao, Zhen Fang Huang and Burdakov, Denis and Sarnyai, Zolt{\'a}n}
}
