@article {69286,
	title = {Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex.},
	journal = {Elife},
	volume = {13},
	year = {2024},
	month = {2024 Mar 12},
	abstract = {<p>The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion signals with external sensory cues. While the anatomical substrates involved in head direction (HD) coding are well known, the mechanisms by which visual information updates HD representations remain poorly understood. Retrosplenial cortex (RSC) plays a key role in forming coherent representations of space in mammals and it encodes a variety of navigational variables, including HD. Here, we use simultaneous two-area tetrode recording to show that RSC HD representation is nearly synchronous with that of the anterodorsal nucleus of thalamus (ADn), the obligatory thalamic relay of HD to cortex, during rotation of a prominent visual cue. Moreover, coordination of HD representations in the two regions is maintained during darkness. We further show that anatomical and functional connectivity are consistent with a strong feedforward drive of HD information from ADn to RSC, with anatomically restricted corticothalamic feedback. Together, our results indicate a concerted global HD reference update across cortex and thalamus.</p>
},
	keywords = {Animals, Anterior Thalamic Nuclei, Cerebral Cortex, Cues, Gyrus Cinguli, Mammals, Mice, Rotation},
	issn = {2050-084X},
	doi = {10.7554/eLife.82952},
	author = {van der Goes, Marie-Sophie H and Voigts, Jakob and Newman, Jonathan P and Toloza, Enrique H S and Brown, Norma J and Murugan, Pranav and Harnett, Mark T}
}
@article {69669,
	title = {ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior.},
	journal = {Nat Methods},
	year = {2024},
	month = {2024 Nov 11},
	abstract = {<p>Behavioral neuroscience faces two conflicting demands: long-duration recordings from large neural populations and unimpeded animal behavior. To meet this challenge we developed ONIX, an open-source data acquisition system with high data throughput (2 GB s) and low closed-loop latencies (\&lt;1 ms) that uses a 0.3-mm thin tether to minimize behavioral impact. Head position and rotation are tracked in three dimensions and used to drive active commutation without torque measurements. ONIX can acquire data from combinations of passive electrodes, Neuropixels probes, head-mounted microscopes, cameras, three-dimensional trackers and other data sources. We performed uninterrupted, long (~7 h) neural recordings in mice as they traversed complex three-dimensional terrain, and multiday sleep-tracking recordings (~55 h). ONIX enabled exploration with similar mobility as nonimplanted animals, in contrast to conventional tethered systems, which have restricted movement. By combining long recordings with full mobility, our technology will enable progress on questions that require high-quality neural recordings during ethologically grounded behaviors.</p>
},
	issn = {1548-7105},
	doi = {10.1038/s41592-024-02521-1},
	url = {https://doi.org/10.1038/s41592-024-02521-1},
	author = {Newman, Jonathan P and Zhang, Jie and Cuevas-L{\'o}pez, Aar{\'o}n and Miller, Nicholas J and Honda, Takato and van der Goes, Marie-Sophie H and Leighton, Alexandra H and Carvalho, Filipe and Lopes, Gon{\c c}alo and Lakunina, Anna and Siegle, Joshua H and Harnett, Mark T and Wilson, Matthew A and Voigts, Jakob}
}
