@article {1766,
	title = {The coding of temperature in the Drosophila brain.},
	journal = {Cell},
	volume = {144},
	year = {2011},
	month = {2011 Feb 18},
	pages = {614-24},
	abstract = {<p>Thermosensation is an indispensable sensory modality. Here, we study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and cold antennal receptors project onto distinct, but adjacent glomeruli in the Proximal-Antennal-Protocerebrum (PAP) forming a thermotopic map in the brain. We use two-photon imaging to reveal the functional segregation of hot and cold responses in the PAP, and show that silencing the hot- or cold-sensing neurons produces animals with distinct and discrete deficits in their behavioral responses to thermal stimuli. Together, these results demonstrate that dedicated populations of cells orchestrate behavioral responses to different temperature stimuli, and reveal a labeled-line logic for the coding of temperature information in the brain.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2011.01.028},
	author = {Gallio, Marco and Ofstad, Tyler A and Macpherson, Lindsey J and Wang, Jing W and Zuker, Charles S}
}
@article {3837,
	title = {Visual place learning in Drosophila melanogaster.},
	journal = {Nature},
	volume = {474},
	year = {2011},
	month = {2011 Jun 9},
	pages = {204-7},
	abstract = {<p>The ability of insects to learn and navigate to specific locations in the environment has fascinated naturalists for decades. The impressive navigational abilities of ants, bees, wasps and other insects demonstrate that insects are capable of visual place learning, but little is known about the underlying neural circuits that mediate these behaviours. Drosophila melanogaster (common fruit fly) is a powerful model organism for dissecting the neural circuitry underlying complex behaviours, from sensory perception to learning and memory. Drosophila can identify and remember visual features such as size, colour and contour orientation. However, the extent to which they use vision to recall specific locations remains unclear. Here we describe a visual place learning platform and demonstrate that Drosophila are capable of forming and retaining visual place memories to guide selective navigation. By targeted genetic silencing of small subsets of cells in the Drosophila brain, we show that neurons in the ellipsoid body, but not in the mushroom bodies, are necessary for visual place learning. Together, these studies reveal distinct neuroanatomical substrates for spatial versus non-spatial learning, and establish Drosophila as a powerful model for the study of spatial memories.</p>
},
	keywords = {Animal, Animals, Brain, Conditioning (Psychology), Cues, Drosophila melanogaster, Female, Glass, Learning, Locomotion, Memory, Models, Mushroom Bodies, Neurological, Odors, Orientation, Silicon Dioxide, Temperature, Time Factors, Visual Perception},
	issn = {1476-4687},
	doi = {10.1038/nature10131},
	author = {Ofstad, Tyler A and Zuker, Charles S and Reiser, Michael B}
}
