@article {69460,
	title = {Dendritic excitations govern back-propagation via a spike-rate accelerometer},
	journal = {Nature Communications},
	volume = {16},
	year = {2025},
	month = {2025 Feb 04},
	abstract = {<p>Dendrites on neurons support nonlinear electrical excitations, but the computational significance of these events is not well understood. We developed molecular, optical, and analytical tools to map sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. We observed history-dependent spike back-propagation in distal dendrites, driven by locally generated Na+ spikes (dSpikes). Dendritic depolarization created a transient window for dSpike propagation, opened by A-type KV channel inactivation, and closed by slow NaV inactivation. Collisions of dSpikes with synaptic inputs triggered calcium channel and N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials, with accompanying complex spikes at the soma. This hierarchical ion channel network acts as a spike-rate accelerometer, providing an intuitive picture of how dendritic excitations shape associative plasticity rules.</p>
},
	doi = {10.1038/s41467-025-55819-9},
	url = {https://www.biorxiv.org/content/early/2024/05/18/2023.06.02.543490},
	author = {Park, Pojeong and Wong-Campos, David and Itkis, Daniel G. and Lee, Byung Hun and Qi, Yitong and Davis, Hunter and Antin, Benjamin and Pasarkar, Amol and Grimm, Jonathan B. and Plutkis, Sarah E. and Holland, Katie L. and Paninski, Liam and Lavis, Luke D. and Cohen, Adam E.}
}
