@article {69510,
	title = {Neocortical inhibitory imbalance predicts successful sensory detection.},
	journal = {Cell Rep},
	volume = {43},
	year = {2024},
	month = {2024 Jun 20},
	pages = {114233},
	abstract = {<p>Perceptual success depends on fast-spiking, parvalbumin-positive interneurons (FS/PVs). However, competing theories of optimal rate and correlation in pyramidal (PYR) firing make opposing predictions regarding the underlying FS/PV dynamics. We addressed this with population calcium imaging of FS/PVs and putative PYR neurons during threshold detection. In primary somatosensory and visual neocortex, a distinct PYR subset shows increased rate and spike-count correlations on detected trials ("hits"), while most show no rate change and decreased correlations. A larger fraction of FS/PVs predicts hits with either rate increases or decreases. Using computational modeling, we found that inhibitory imbalance, created by excitatory "feedback" and interactions between FS/PV pools, can account for the data. Rate-decreasing FS/PVs increase rate and correlation in a PYR subset, while rate-increasing FS/PVs reduce correlations and offset enhanced excitation in PYR neurons. These findings indicate that selection of informative PYR ensembles, through transient inhibitory imbalance, is a common motif of optimal neocortical processing.</p>
},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2024.114233},
	author = {Deister, Christopher A and Moore, Alexander I and Voigts, Jakob and Bechek, Sophia and Lichtin, Rebecca and Brown, Tyler C and Moore, Christopher I}
}
