@article {69534,
	title = {Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching.},
	journal = {Cell},
	year = {2024},
	month = {2024 Jul 03},
	abstract = {<p>In developing brains, axons exhibit remarkable precision in selecting synaptic partners among many non-partner cells. Evolutionarily conserved teneurins are transmembrane proteins that instruct synaptic partner matching. However, how intracellular signaling pathways execute teneurins{\textquoteright} functions is unclear. Here, we use in situ proximity labeling to obtain the intracellular interactome of a teneurin (Ten-m) in the Drosophila brain. Genetic interaction studies using quantitative partner matching assays in both olfactory receptor neurons (ORNs) and projection neurons (PNs) reveal a common pathway: Ten-m binds to and negatively regulates a RhoGAP, thus activating the Rac1 small GTPases to promote synaptic partner matching. Developmental analyses with single-axon resolution identify the cellular mechanism of synaptic partner matching: Ten-m signaling promotes local F-actin levels and stabilizes ORN axon branches that contact partner PN dendrites. Combining spatial proteomics and high-resolution phenotypic analyses, this study advanced our understanding of both cellular and molecular mechanisms of synaptic partner matching.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2024.06.022},
	author = {Xu, Chuanyun and Li, Zhuoran and Lyu, Cheng and Hu, Yixin and McLaughlin, Colleen N and Wong, Kenneth Kin Lam and Xie, Qijing and Luginbuhl, David J and Li, Hongjie and Udeshi, Namrata D and Svinkina, Tanya and Mani, D R and Han, Shuo and Li, Tongchao and Li, Yang and Guajardo, Ricardo and Ting, Alice Y and Carr, Steven A and Li, Jiefu and Luo, Liqun}
}
