@article {69611,
	title = {Sub-threshold neuronal activity and the dynamical regime of cerebral cortex.},
	journal = {Nat Commun},
	volume = {15},
	year = {2024},
	month = {2024 Sep 11},
	pages = {7958},
	abstract = {<p>Cortical neurons exhibit temporally irregular spiking patterns and heterogeneous firing rates. These features arise in model circuits operating in a {\textquoteright}fluctuation-driven regime{\textquoteright}, in which fluctuations in membrane potentials emerge from the network dynamics. However, it is still debated whether the cortex operates in such a regime. We evaluated the fluctuation-driven hypothesis by analyzing spiking and sub-threshold membrane potentials of neurons in the frontal cortex of mice performing a decision-making task. We showed that while standard fluctuation-driven models successfully account for spiking statistics, they fall short in capturing the heterogeneity in sub-threshold activity. This limitation is an inevitable outcome of bombarding single-compartment neurons with a large number of pre-synaptic inputs, thereby clamping the voltage of all neurons to more or less the same average voltage. To address this, we effectively incorporated dendritic morphology into the standard models. Inclusion of dendritic morphology in the neuronal models increased neuronal selectivity and reduced error trials, suggesting a functional role for dendrites during decision-making. Our work suggests that, during decision-making, cortical neurons in high-order cortical areas operate in a fluctuation-driven regime.</p>
},
	keywords = {Action Potentials, Animals, Cerebral Cortex, Decision Making, Dendrites, Frontal Lobe, Male, Membrane Potentials, Mice, Mice, Inbred C57BL, Models, Neurological, Neurons},
	issn = {2041-1723},
	doi = {10.1038/s41467-024-51390-x},
	url = {https://doi.org/10.1038/s41467-024-51390-x},
	author = {Amsalem, Oren and Inagaki, Hidehiko and Yu, Jianing and Svoboda, Karel and Darshan, Ran}
}
