@article {69732,
	title = {A critical initialization for biological neural networks},
	journal = {Nature},
	year = {2026},
	month = {2026 May 20},
	abstract = {<p>Intrinsically generated, brainwide neural activity displays macroscopic coordination among large populations of neurons that persists beyond the biophysical timescales of individual neurons1-3. It is not well understood how these macroscopic behaviours arise from microscopic, short-lived interactions between pairs of neurons. Here we show that the eigenvalue spectrum and dynamical properties of large-scale neural recordings in mice are similar to those produced by linear dynamics governed by a random symmetric matrix that is critically normalized. An exception was population activity in hippocampal area CA1, which resembled an efficient, uncorrelated neural code that may be optimized for information storage capacity. High-dimensional, global activity modes emerged in critically normalized artificial networks and persisted under sparse, clustered or spatial connectivity. These dynamics were useful for solving time-dependent tasks such as a zero-shot working memory task.</p>
},
	doi = {10.1038/s41586-026-10528-1},
	url = {https://doi.org/10.1038/s41586-026-10528-1},
	author = {Pachitariu, Marius and Zhong, Lin and Gracias, Alexa and Minisi, Amanda and Lopez, Crystall and Stringer, Carsen}
}
@article {70354,
	title = {Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators.},
	journal = {Science},
	volume = {392},
	year = {2026},
	month = {2026 Apr 09},
	pages = {eaea2100},
	abstract = {<p>At the blood-tissue interface, vasculature luminal surface is critical for molecular transport, signaling transduction, and cell extravasation. Here, we present a method for proteomic profiling of the vasculature luminal surface in vivo, broadly applicable to any vertebrate. Quantitative mass spectrometry revealed the luminal surface proteome of the mouse brain vasculature and its temporal evolution from development to aging. In vivo genetic perturbation found that the arginine transporter SLC7A1 and the nitric oxide synthase NOS3 are needed for blood-brain barrier integrity in neonatal but not adult mice, whereas the hyaluronan degradation enzyme HYAL2 safeguards the barrier throughout the lifespan. By characterizing the proteomic dynamics of the vasculature luminal surface, the study links the metabolism of nitric oxide and hyaluronan to blood-brain barrier integrity.</p>
},
	keywords = {Aging, Animals, Blood-Brain Barrier, Brain, Cell Adhesion Molecules, Hyaluronic Acid, Mice, Nitric Oxide, Nitric Oxide Synthase Type III, Proteome, Proteomics},
	issn = {1095-9203},
	doi = {10.1126/science.aea2100},
	url = {https://doi.org/10.1126/science.aea2100},
	author = {Zhu, Zijian and Jiang, Zuzhi and Wang, Yupu and Nguyen, Khanh and Zhang, Yuxiang and Lian, Cameron Genxuan and Mani, D R and Zheng, Jun and Ding, Lang and Gao, Shihong Max and Xia, Ruyue Alps and Kuszpit, Anne and Lindo, Sarah and Lopez, Crystall and Lindsey, Catherine and Groff, Brooke and Chen, Xinhong and Wu, Jiahui and Xia, Weiliang and Li, Wei and Liu, Xiaorong and Gradinaru, Viviana and Carr, Steven A and Udeshi, Namrata D and Li, Jiefu}
}
