@article {70189,
	title = {Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space},
	journal = {bioRxiv},
	year = {2025},
	month = {2025 Nov 14},
	abstract = {<p>The timing of spikes dictates a neuron{\textquoteright}s impact on downstream circuits and behavior, and spike timing is determined by the membrane potential (Vm). However, due to technical challenges, it has been impossible to analyze the relative timing of Vm dynamics between neurons during behavior. Using large scale membrane voltage imaging, we simultaneously recorded Vm from many individual hippocampal neurons in animals engaged in a virtual spatial task. We found that relative phase of Vm theta oscillations across neurons exhibit gradual or discrete shifts depending on spatial position. This finding extends beyond previous studies showing Vm dynamics in single neurons or spiking activity in multiple neurons, revealing previously unknown evidence for consistent coding of space by spike-independent relative phase of Vm theta dynamics between neurons.</p>
},
	doi = {10.1101/2025.11.14.688496},
	url = {https://www.biorxiv.org/content/early/2025/11/14/2025.11.14.688496},
	author = {Athif, Mohamed and Malmberg, Samantha and Mount, Rebecca and Patel, Kush and Wang, Yangyang and Shaw, Dana and Ravasio, Cara and Xiao, Sheng and Rillosi, Enrico and Tseng, Hua-An and Plutkis, Sarah E. and Grimm, Jonathan B. and Lavis, Luke D. and Mertz, Jerome and Han, Xue and Hasselmo, Michael E.}
}
