@article {46664,
	title = {A cellular resolution map of barrel cortex activity during tactile behavior.},
	journal = {Neuron},
	volume = {86},
	year = {2015},
	month = {2015 Apr 21},
	pages = {783-99},
	abstract = {<p>Comprehensive measurement of neural activity remains challenging due to the large numbers of neurons in each brain area. We used volumetric two-photon imaging in mice expressing GCaMP6s and nuclear red fluorescent proteins to sample activity in 75\% of superficial barrel cortex neurons across the relevant cortical columns, approximately 12,000 neurons per animal, during performance of a single whisker object localization task. Task-related activity peaked during object palpation. An encoding model\&nbsp;related activity to behavioral variables. In the column corresponding to the spared whisker, 300 layer (L) 2/3 pyramidal neurons (17\%) each encoded touch and whisker movements. Touch representation declined by half in surrounding columns; whisker movement representation was unchanged. Following the emergence of stereotyped task-related movement, sensory representations showed no measurable plasticity. Touch direction was topographically organized, with distinct organization for passive and active touch. Our work reveals sparse and spatially intermingled representations of multiple tactile features.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2015.03.027},
	author = {Peron, Simon P and Freeman, Jeremy and Iyer, Vijay and Guo, Caiying and Svoboda, Karel}
}
@article {4289,
	title = {Neural activity in barrel cortex underlying vibrissa-based object localization in mice.},
	journal = {Neuron},
	volume = {67},
	year = {2010},
	month = {2010 Sep 23},
	pages = {1048-61},
	abstract = {<p>Classical studies have related the spiking of selected neocortical neurons to behavior, but little is known about activity sampled from the entire neural population. We recorded from neurons selected independent of spiking, using cell-attached recordings and two-photon calcium imaging, in the barrel cortex of mice performing an object localization task. Spike rates varied across neurons, from silence to \&gt;60 Hz. Responses were diverse, with some neurons showing large increases in spike rate when whiskers contacted the object. Nearly half the neurons discriminated object location; a small fraction of neurons discriminated perfectly. More active neurons were more discriminative. Layer (L) 4 and L5 contained the highest fractions of discriminating neurons (\~{}63\% and 79\%, respectively), but a few L2/3 neurons were also highly discriminating. Approximately 13,000 spikes per activated barrel column were available to mice for decision making. Coding of object location in the barrel cortex is therefore highly redundant.</p>
},
	keywords = {Action Potentials, Afferent Pathways, Animal, Animals, Behavior, Biological, Brain Mapping, Calcium, Discrimination (Psychology), Inbred C57BL, Male, Mice, Models, Neurons, Physical Stimulation, ROC Curve, Somatosensory Cortex, Vibrissae},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2010.08.026},
	author = {O{\textquoteright}Connor, Daniel H and Peron, Simon P and Huber, Daniel and Svoboda, Karel}
}
