@article {70292,
	title = {Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.},
	journal = {Neuroscience},
	year = {2026},
	month = {2026 Feb 12},
	abstract = {<p>Coordinated lateralized movements are critical for natural orienting behaviors, but their neural bases remain poorly understood. The deep superior colliculus (dSC) integrates a wide range of inputs to select targets for orienting movements and coordinates downstream activity to initiate and execute movement. The substantia nigra pars reticulata (SNr) is thought to disinhibit dSC to facilitate movement, but much remains unknown about the relationship between SNr activity, dSC activity, and movement. We recorded from both regions using high-density probes in head-fixed mice performing directional orienting tasks. We found that dSC and SNr activity reflected task variables preceding and throughout movement. However, the direction-dependence of dSC activity was weaker than in other orienting behaviors, and the relationship between movement-related dSC and SNr activity was inconsistent with disinhibition of dSC determining the initiation or direction of movement. Analyses of similar data curated by the International Brain Laboratory yielded consistent results. These findings suggest diverse roles for modulatory input from SNr to dSC in shaping motor behavior.</p>
},
	issn = {1873-7544},
	doi = {10.1016/j.neuroscience.2026.02.010},
	url = {https://doi.org/10.1016/j.neuroscience.2026.02.010},
	author = {Doykos, Ted K and Yamauchi, Taylor and Buteau, Anna and Hanson, Spencer and Dudman, Joshua T and Felsen, Gidon and Stubblefield, Elizabeth A}
}
