@article {49059,
	title = {Integrative whole-brain neuroscience in larval zebrafish.},
	journal = {Current Opinion in Neurobiology},
	volume = {50},
	year = {2018},
	month = {2018 Feb 24},
	pages = {136-145},
	abstract = {<p>Due to their small size and transparency, zebrafish larvae are amenable to a range of fluorescence microscopy techniques. With the development of sensitive genetically encoded calcium indicators, this has extended to the whole-brain imaging of neural activity with cellular resolution. This technique has been used to study brain-wide population dynamics accompanying sensory processing and sensorimotor transformations, and has spurred the development of innovative closed-loop behavioral paradigms in which stimulus-response relationships can be studied. More recently, microscopes have been developed that allow whole-brain calcium imaging in freely swimming and behaving larvae. In this review, we highlight the technologies underlying whole-brain functional imaging in zebrafish, provide examples of the sensory and motor processes that have been studied with this technique, and discuss the need to merge data from whole-brain functional imaging studies with neurochemical and anatomical information to develop holistic models of functional neural circuits.</p>
},
	issn = {1873-6882},
	doi = {10.1016/j.conb.2018.02.004},
	author = {Vanwalleghem, Gilles C and Ahrens, Misha B and Scott, Ethan K}
}
@article {4369,
	title = {Filtering of visual information in the tectum by an identified neural circuit.},
	journal = {Science},
	volume = {330},
	year = {2010},
	month = {2010 Oct 29},
	pages = {669-73},
	abstract = {<p>The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter γ-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.</p>
},
	keywords = {Animals, Axons, Bicuculline, Dendrites, GABA Antagonists, gamma-Aminobutyric Acid, Genetically Modified, Interneurons, Neural Inhibition, Neurons, Neuropil, Nonmammalian, Optic Lobe, Photic Stimulation, Retina, Retinal Neurons, Synaptic Transmission, Visual Pathways, Visual Perception, Zebrafish},
	issn = {1095-9203},
	doi = {10.1126/science.1192949},
	author = {Del Bene, Filippo and Wyart, Claire and Robles, Estuardo and Tran, Amanda and Looger, Loren and Scott, Ethan K and Isacoff, Ehud Y and Baier, Herwig}
}
